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This paper makes an important contribution, by documenting changes in the mutation spectrum during human evolution. It presents an analysis of population differences in the spectrum of context dependent single nucleotide polymorphism, focused on humans and great apes.

A previous observation about differences in mutation spectrum between human populations is replicated here and a hypothesis about a historical burst of mutation is presented. Many additional, weaker differences are also seen but replicated across data sets, which argues for biological, rather than experimental explanations.

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